Background
Last night Ubuntu released a patch for libmysqlclient21
which includes a MySQL update that affects Perl.
/etc/webmin/status/monitor.pl
is run every 5 mins and calls /usr/share/webmin/status/monitor.pl
which then calls /usr/share/webmin/status/mysql-monitor.pl
which in turn calls /usr/share/webmin/mysql/mysql-lib.pl
and that shows that the entire way that Webmin is authenticating with MySQL is via the deprecated call 
Workarounds
Option 1) Roll back the affected package and hold it…
$ sudo apt list -a libmysqlclient21
libmysqlclient21/focal-updates,focal-security,now 8.0.34-0ubuntu0.20.04.1 amd64 [installed,automatic]
libmysqlclient21/focal 8.0.19-0ubuntu5 amd64
$ sudo apt install libmysqlclient21=8.0.19-0ubuntu5
$ sudo apt-mark hold libmysqlclient21
Option 2) Edit the cron to grep out the warning
$ sudo crontab -e
change
0,5,10,15,20,25,30,35,40,45,50,55 * * * * /etc/webmin/status/monitor.pl
… to…
0,5,10,15,20,25,30,35,40,45,50,55 * * * * /etc/webmin/status/monitor.pl 2>&1 | grep -v "MYSQL_OPT_RECONNECT is deprecated"
Hopefully a fix will be out soon