Setting up e-mail management

Trying to solve but something is really beyond my knowledge. As suggested in this post by @Joe:

Pick one (1) domain to use for mail, and click “Copy to Postfix”. Stop there. You’re done. Use that domain for anything that interacts with SMTP, always

I copied to Postfix but I continue to not receive e-mails. Do I have also Set as default services certificate?

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Moreover, when I ask to Read mail in file or Maildir

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the answer is: Failed to open Maildir/ : No such file or directory

Does it have anything to do with my issue?

Thank you all for any further assistance.