Refused to connect

OS version:
ubuntu 18.04

I’ve been always using myServerIP:10000 to log into virtualmin.
Recently I started to get “refused to connect” error as I try to open it. My websites are running well, just can’t get to virtualmin backend. If I reboot the machine, it will let me connect. But after a while somehow this happens again.
I haven’t touched my server setting for a long time, so I really don’t know what could possibly cause this.

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